'Seronegative' myasthenia gravis is no longer seronegative
نویسندگان
چکیده
منابع مشابه
Double seronegative myasthenia gravis with antiphospholipid syndrome: a case report
INTRODUCTION Myasthenia gravis is an autoimmune disease characterized by fluctuating muscle weakness. It is often associated with other autoimmune disorders, such as thyroid disease, rheumatoid arthritis, systemic lupus erythematosus, and antiphospholipid syndrome. Many aspects of autoimmune diseases are not completely understood, particularly when they occur in association, which suggests a co...
متن کاملIgG1 antibodies to acetylcholine receptors in ‘seronegative’ myasthenia gravis†
Only around 80% of patients with generalized myasthenia gravis (MG) have serum antibodies to acetylcholine receptor [AChR; acetylcholine receptor antibody positive myasthenia gravis (AChR-MG)] by the radioimmunoprecipitation assay used worldwide. Antibodies to muscle specific kinase [MuSK; MuSK antibody positive myasthenia gravis (MuSK-MG)] make up a variable proportion of the remaining 20%. Th...
متن کاملSeronegative Maternal Ocular Myasthenia Gravis and Delayed Transient Neonatal Myasthenia Gravis
Background Myasthenia gravis (MG) is an autoimmune disorder with fluctuating muscle weakness, divided into generalized and localized (ocular) forms. Maternal antibodies to acetylcholine receptors cross the placenta and may cause transient neonatal myasthenia gravis (TNMG). We present a case of seronegative maternal ocular MG and delayed TNMG. Case A 29-year-old G3P1011 underwent cesarean birth ...
متن کاملKey words: seronegative myasthenia gravis, muscle atrophy, muscle-specific receptor tyrosine kinase (MuSK) antibody, tongue atrophy Myasthenia gravis
Myasthenia gravis (MG) is an autoimmune disorder with easy fatigability of the muscles based on a neuromuscular transmission defect. Most myasthenic patients have antiacetylcholine receptor antibodies which attach to the acetycholine receptor of the postsynaptic membrane of the skeletal muscles and decrease the amplitude of miniature endplate potentials (mepp) and endplate potentials (epp) caus...
متن کاملDouble Seronegative Myasthenia Gravis with Anti-LRP4 Antibodies Presenting with Dropped Head and Acute Respiratory Insufficiency
We herein report the case of a 72-year-old man demonstrating myasthenia gravis (MG) with a dropped head and acute respiratory insufficiency. There was no ocular, bulbar, or limb involvement. The patient was seronegative for anti-acetylcholine receptor (AChR) antibodies and anti-muscle-specific tyrosine kinase (MuSK) antibodies. Subsequent tests showed seropositivity for anti-low-density lipopro...
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ژورنال
عنوان ژورنال: Brain
سال: 2008
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/awn131